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A 2022 meta-analysis in Frontiers in Nutrition analyzed 49 studies of berberine supplementation lasting four to 104 weeks in adults, aged 25 to 65 on average

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Owing to its transient effects, invasiveness, and potential adverse impacts, bloodletting is not recommended as a long-term treatment for CMS

The antibodies used for the immunoblot assays were: GCLC (Santa Cruz Biotech, #sc-390811), NQO1 (Sigma Prestige Antibodies, HPA007308), ACTIN (Sigma, A1978), NRF2 (Cell Signaling Technology, #12721), NRF1 (Cell Signaling Technology, #8052), YAP/TAZ (Cell Signaling, #8418) 4-HNE (Abcam, #ab46545) and Lamin A/C (Cell Signaling, #4777)

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