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As of 2026, the introduction of Glucagon-like peptide-1 (GLP-1) and dual GIP/GLP-1 receptor agonists (such as semaglutide, tirzepatide, and exenatide) has opened a new frontier in the conservative management of lipoedema

Table 3 Drugs that inhibit synthesis of derived fatty acids

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Since calcium signaling is required for many pro-inflammatory cascades, this hyperpolarization effectively puts the brakes on inflammatory cytokine production

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