Multiple well-designed clinical trials have demonstrated SFNs biological activity and therapeutic potential, while also revealing important considerations for its clinical implementation ( Figure 3 )
If a third pathway proves beneficial, you simply add a third compound
mPFC, Medial Prefrontal Cortex
For others, traditional remedies might be the better choice
Kotronen A, Seppala-Lindroos A, Vehkavaara S, Bergholm R, Frayn KN, Fielding BA, Yki-Jarvinen H (2009) Liver fat and lipid oxidation in humans
Additionally, the colloidal stability of SPIONs may constrain their applications in MRI