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This receptor modulation triggers a cascade of intracellular signaling events that ultimately result in the activation of hormone-sensitive lipase, the enzyme responsible for breaking down stored triglycerides into free fatty acids and glycerol
Conversely, AOD-9604 acts more like a targeted 'fat mobilizer.' It's directly involved in prompting adipocytes to release stored fat and hindering new fat accumulation
Thus, a higher Bcl-2/Bax ratio is posted as a predominance of Bcl-2, which may inhibit apoptosis and apparently promotes cell survival
However, GLP-1 agonists have limitations
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