These agents have become foundational agents in adjunctive liver therapy
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From an implementation standpoint, the standardized liquid formulation enables rapid local absorption with minimal systemic exposure and ensures uniform mucosal coverage, consistent dosing, and prolonged mucosal contact, features likely to reduce the formulation heterogeneity that has hampered prior topical studies and to enhance adherence 21
One patient was reported to have learning disability with dyslexia and was also thought to be mentally retarded [5], and another had delayed psychomotor development and progressive sensory neuropathy of lower extremities, ataxia, hyperreflexia, dysarthria, and a peculiar gait suggestive of spinocerebellar degeneration [2]
Correale J, Hohlfeld R, Baranzini SE
The long-term effects of maternal deprivation on the number and size of inhibitory interneurons in the rat amygdala and nucleus accumbens