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"Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways"

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Testicular torsion was induced for 3 h, followed by 24 h of reperfusion

PMID 25820384

The review warns that since VEGF/VEGFR2 pathways are active in roughly half of human cancers (from ovarian to melanoma)

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