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(2) synthesis of the polyisoprenoid side chain from acetyl-coenzyme A (CoA) via the mevalonate pathway

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These actions occur continuously once therapeutic levels are established, regardless of when the injection is administered

doi: 10.1371/journal.pone.0280548 139 ZhangXZhangYWeiJLiXJiangAShenYet al

When you move up to a new dose, the first two to three weeks typically bring more pronounced side effects than the maintenance phase at that dose