Pay in 4 interest-free payments of $7.45 Learn more
Ships within 48 hours · Estimated delivery Sep 24 - Sep 29
doi: 10.1210/clinem/dgz140, 74 Kaiser Family, F (2024)
5-Amino-1MQ Key Research Facts Chemical name: 5-Amino-1-Methylquinolinium (also abbreviated as 5A-1MQ or 5MQ) Target enzyme: Nicotinamide N-Methyltransferase (NNMT) Mechanism: Competitive inhibition of NNMT reduces 1-MNA production, preserves nicotinamide for NAD+ synthesis and SAM for epigenetic methylation Selectivity: High selectivity for NNMT does not inhibit related SAM-dependent methyltransferases or NAD+ salvage pathway enzymes Membrane permeability: High passive and active transport permeability confirmed in PAMPA and Caco-2 cell assays NNMT expression: Upregulated in obese adipose tissue, multiple cancer types, and aged skeletal muscle tissue contexts of primary research interest Downstream targets: NAD+ availability, SIRT1/SIRT3 activity, SAM-dependent epigenetic methylation, lipogenesis, energy expenditure Pre-clinical models: Diet-induced obese (DIO) mice, 3T3-L1 adipocyte cell models, aged mouse skeletal muscle models, HeLa cancer cell lines In vitro cell viability: No impact on cell viability at 10 M concentration in 3T3-L1 pre-adipocytes in published toxicity profiling What Does 5-Amino-1MQ Do in Research
Most peptides degrade in the digestive system, making injectable administration standard
Article 8 mins Decarbonizing Your Business: Finding the Right Insurance and Strategy Lowering greenhouse gas emissions is a growing priority, but successful industrial decarbonization requires a clear view of regulations and risk
These foods include plain yogurt, kefir, sauerkraut, kombucha and kimchi, which contain helpful bacteria from the fermentation process
Children : Paediatric use should only occur under specialist supervision, typically in diagnosed deficiency states or specific metabolic disorders
US$ 22.89
US$ 23.79
US$ 21.03
US$ 27.04
