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Recent studies show that sodium-glucose cotransporter 2 (SGLT2) inhibitors can not only protect the kidneys by reducing blood sugar, improving hemodynamics and reducing proteinuria (Martinez Leon et al., 2026), but also inhibit ferroptosis by restoring iron homeostasis, limiting lipid peroxidation and enhancing antioxidant systems (Tsai et al., 2025)
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Hypoxia and matrix metalloproteinase 13Responsive hydrogel microspheres alleviate osteoarthritis progression in vivo
Research has revealed a unique protease activation phenomenon in MELAS: LONP1 exhibits subcellular compartmentalized aggregation in primary cells from patients with MELAS, with its protein abundance particularly elevated in cell populations enriched with mutant mtDNA