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If the gallbladder was removed due to acute cholecystitis, gallstone pancreatitis, or biliary complications, it is prudent to ensure complete recovery and resolution of any inflammatory processes before initiating weight loss therapy

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In a phase II trial, participants with obesity were randomly assigned to various doses of retatrutide from 14 , 8, or 12 mg or a placebo for 48 weeks [19]

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Each subunit contains an IgG1 Fc carrier domain linked covalently to the peptide molecule