Volume growth in animal cells is cell cycle dependent and shows additive fluctuations
A gain-of-function mutation in a proto-oncogene converts it into an oncogene, producing tumour-promoting proteins, whereas a mutation in a tumour suppressor gene leads to loss of function, impairing its ability to regulate cell growth
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We also provide an update on the targets and clinical prospects of different antioxidants (melatonin, N-acetylcysteine, vitamins, -lipoic acid, mineral elements, phytochemicals, nutritional antioxidants, cytoprotectants and synthetic compounds) in the treatment of CIPN with the help of preclinical and clinical studies, emphasizing the great potential of antioxidants as adjuvant strategies to mitigate CIPN