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Long-term use is required to maintain weight loss, and when people stop taking them it usually results in weight regain
New England Journal of Medicine, 349(17), 1605-1613
Doctors generally follow established criteria similar to other weight-loss medications: a patient should have a BMI of 30 kg/m2 or above (obesity), or at least 27 kg/m2 with a weight-related health condition like high blood pressure, diabetes, or sleep apnea
Worley summarizes
Nature of glomerular capillary permeability changes following acute renal ischemia-reperfusion injury in rats
"We are encouraged by the results which highlight the powerful effect of retatrutide, a first-in-class triple agonist, on body weight, pain and physical function
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