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Simic-OgrizovicS.SimicT.ReljicZ.MarkovicS.BlagojevicR.RadivojevicD.LezaicV.DjukanovicL.Mimic-OkaJ.1998Markers of oxidative stress after renal transplantation.125-S129
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The endogenous mechanism is triggered by the depletion of intracellular glutathione (GSH) and inactivation of GSH peroxidase 4 (GPX4) (Masaldan et al., 2019), cardiomyopathy (Timmers et al., 2020), atherosclerosis (Ouyang et al., 2021), liver injury (Tonnus et al., 2021), or related pathological cell death
Case of the Month The RECNAC II Project by Michael Gonzalez, Ph.D
They also highlight a recurring pattern in peptide drug development: early safety signals, particularly those observed at supraphysiologic exposure levels or in non-human models, have frequently led to premature abandonment of otherwise biologically compelling targets
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