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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

Jansen M et al

Pregnant or breastfeeding women and people with certain illnesses should avoid IVs or injections unless a doctor clears them

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