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SAMe is biochemically produced through the folate-methionine cycle (see Figure 1), requiring many nutrients, including vitamin B12 and the healthy conversion of folic acid to 5-methyltetrahydrofolate (Guildford, n.d.)

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Additional areas of active investigation include the peptide's potential effects on bone healing, where studies have reported accelerated fracture consolidation in animal models

For the maintenance treatment of pernicious anemia, the usual dose is 100mcg SC/IM, given once every month

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