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Together, we conclude that -KG insufficiency disrupts mitochondrial homeostasis to deplete cytosolic NADPH under glucose starvation, functionally eliciting disulfidptosis
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Myeloperoxidase (MPO) activity, a marker for neutrophil infiltration, was measured in lung tissue homogenates using a previously described spectrophotometric method, assessing HO-dependent o-dianisidine oxidation
The side effects also differ
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