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Tirzepatide's Zepbound label reports similar figures, with nausea at 31% and constipation at 17% at the 15 mg dose in SURMOUNT-1 [2][4]

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The safety considerations for Wnt-targeting topical compounds are distinct from those for systemic Wnt pathway modulation, though pre-clinical safety data and the absence of human trial data mean these considerations have not been fully characterised

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