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The SURMOUNT-4 randomized clinical trial assessed the effect of tirzepatide discontinuation on the maintenance of weight reduction in adults with obesity and a weight-related complication, excluding diabetes
Some options include weight maintenance support groups, which can offer a safe space for encouragement, sharing experiences, and providing practical tips for sustaining weight loss
Data were acquired with the Analyst Software (ver 1.6.2) and quantification performed using the Multiquant Software (ver 3.0.1)
The STEP-OSA trials showed that semaglutide 2.4 mg reduced the apnea-hypopnea index by approximately 40% at 52 weeks in adults with moderate-to-severe OSA and obesity [14]
The clinical results reflect what's possible when medication is paired with a reduced-calorie diet and increased physical activity, which is also how it's indicated for use in real-world treatment
Eggers test revealed significant publication bias for some outcomes at three months, with no evidence of bias for most outcomes at other time points
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