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The above is summarized in the following graph: Adrenal Exhaustion While Stage 1 (flight or fight response) and Stage 2 (organ resistance) of Adrenal Fatigue have been studied from a patho-physiological perspective for some decades, our clinical understanding of the myriad of symptoms and their convoluted presentations in Stage 3 (Adrenal Exhaustion) is still in its infancy at best

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We also included mechanistic evidence from young healthy adults and animal studies to help support and interpret findings from human studies when available and appropriate