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There is currently no significant body of scientific evidence from human clinical trials to suggest that it directly stimulates lipolysis (the breakdown of fat) or dramatically boosts metabolic rate in the way that compounds like caffeine, ephedrine, or even proven medications do

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Curr Opin Pharmacol 8, 616619, doi: 10.1016/j.coph.2008.06.002 (2008)

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In contrast, truncation of the first two residues of exendin-4 does not significantly alter its affinity but does lower potency for cAMP signalling by ~200-fold 23,24,25

Otherwise, peptides remain a needle market that is very limited