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It has further surprisingly and unexpectedly been found that multiple agent therapy, such as wherein each agent is independently a sub-therapeutic dose, with either sequential or concurrent administration of the agents, will produce the desired pharmacological response, such as an erection sufficient for sexual intercourse, with higher reliability than does a higher dose of either agent administered as monotherapy that in some instances produces the desired pharmacological response

These effects potentially spur muscle gain, weight gain, and overall strength

However, excess selenium may contribute to oxidative stress rather than relieve it

Oxidative Med Cell Longev 2015:986075 Choi Y-J, Kang J-S, Park JHY, Lee Y-J, Choi J-S, Kang Y-H (2003) Polyphenolic flavonoids differ in their antiapoptotic efficacy in hydrogen peroxidetreated human vascular endothelial cells

Measurable weight loss appears around weeks 4 to 8 as the dose titrates up