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The extended development timeline reflects the comprehensive data package required for approval of a novel triple-receptor agonist
The effect of tirzepatide on stomach emptying is generally strongest after the first dose and may become less pronounced after subsequent doses
Crucially, the drug did not directly affect cancer cell proliferation
The dropout rate, which the cultural narrative tends to elide, is significant, somewhere between 10% and 25% of patients discontinue within the first year, the majority due to gastrointestinal side effects that for some are tolerable nuisance and for others are quality-of-life-destroying
2001 , pe3 (2001)
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