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No direct human cases of MTC caused by tirzepatide have been confirmed, but the FDA and Eli Lilly require the warning because the mechanistic concern applies to the entire GLP-1 class
One such class of transcription factor proteins is the FOXO group or forkhead family of transcription factor-O, (2) which includes four members: FOXO1, FOXO3, FOXO4, and FOXO6
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