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Mechanistically, a 2026 PubMed review points to angiogenesis, collagen synthesis, fibroblast activity, and nitric oxide modulation as the likely pathways
ANZ J Surg
The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice
They also have different ways of measuring the active ingredient, so products can vary significantly
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