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Lillys triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial. Press Release, December 11, 2025

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Unlike Ozempic, which works through GLP-1 alone, retatrutide adds GIP and glucagon receptor activity on top of the GLP-1 backbone

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Small changeslike portion size, meal timing, and food choicescan make a big difference in how you feel and how well the medication works