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Eur Arch Otorhinolaryngol 269:21852188 Esterberg R, Linbo T, Pickett SB, Wu P, Ou HC, Rubel EW, Raible DW (2016) Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death

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When fermented, it produces SCFAs like butyrate and propionate, compounds shown to interact with L-cells and stimulate GLP-1 secretion

While co-treatment with 300 nM Ex-4 during differentiation suppressed osteogenic marker expression of RUNX2 , bone morphogenetic protein 2 ( BMP2 ), ALP and matrix deposition, early exposure prior to differentiation start or at the time of cell isolation, enhanced osteogenic marker expression [15]

Mechanisms include altered gut motility, changes in intestinal fluid secretion, and microbiome shifts

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