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That's a genuine overlap between traditional and modern approaches

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In SURMOUNT-4 (Aronne et al., *JAMA* 2024), all patients ran an open-label phase reaching maximum tolerated dose (10 mg or 15 mg weekly) for 36 weeks, losing an average of 20.9% of body weight in that phase

GLP-1 receptor agonists enhance glucose-dependent insulin secretion, meaning they help your pancreas release more insulin when blood sugar rises after meals