In isolation, glucagon receptor activation is associated with hepatic glucose output and lipolysis, effects traditionally viewed as counter-regulatory
Her weight climbed again
Some people carry genetic variants that affect how their bodies respond to GLP-1 receptor activation
Morris G, Anderson G, Dean O, Berk M, Galecki P, Martin-Subero M, Maes M
In one published case, an active, lean-adjacent man lost about one-third of his total weight as muscle on 2.5 mg and recovered it after adding resistance training and increasing protein. This is a cautionary case, not an incidence estimate
Healthline notes that prescriptions typically require a BMI of 30 or higher, but the evaluation goes beyond just one number