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In animal models finerenone reduced the expression of genes encoding monocyte chemoattractant protein-1, matrix metalloproteinase-2 and plasminogen activator inhibitor-1 (related to tissue remodelling and fibrosis) in the kidney, and additionally demonstrated beneficial immunomodulatory effects [73]
[PMID: 6430725] PubMed record related to this compound for laboratory literature review
mansoni GST (Figure 1C)
Over a year of weekly injections, that adds up
Loss of appetite While this supports weight loss, excessive loss of appetite may require dietary adjustments
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