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Related to vasodilation

However, high doses can cause: Stomach upset or diarrhea Kidney stones in susceptible individuals Iron absorption issues if you have iron overload conditions People with kidney problems should be cautious with high-dose vitamin C supplements

Arch Pharmacol

Glutathione actively fights various oxidants including superoxide anion, hydroxyl radical, and nitric oxide

In the liver, it offers antioxidant support for liver tissue protection and promotes p450 phase II conjugation pathways to support detoxification

Melanie Avalon: And people will often say that coffee enemas increase glutathione production