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(60) have reviewed the HOTYR ability to modulate the transcription factor NF-B whose activation triggers the expression of over 150 genes, including those encoding cytokines, such as tumor necrosis factor alpha (TNF-), interleukin (IL)-1, IL-6, and IL-17, chemokines and adhesion molecules, implicated in both physiological and pathophysiological inflammatory responses

Veronese N, et al

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Food and Drug Administration Updated 503A bulk drug substances list (Category 2 revision, effective April 22, 2026)