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Annu Rev Physiol

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Skin folds (elbows, behind knees, groin, armpits), the face, and neck tend to be particularly susceptible

In preclinical models it has been associated with cytoprotection , modulation of nitric-oxide pathways and angiogenesis , with reported activity across gastrointestinal, musculoskeletal and other tissues [1] [2]

NNMT expression has been found to be elevated in white adipose tissue and correlates with obesity and metabolic dysfunction in various studies

Immune System Support Vitamin D is well-known for its role in enhancing immune system function, as it helps activate cells that combat infections and reduces inflammation