triagonism) on energy expenditure, glucose regulation, food intake, and weight loss in a well-established DIO mouse model in comparison to clinically relevant GLP1 receptor agonists [83]
A recent Evidation survey found that roughly one in seven GLP-1 users takes a lower dose than prescribed
Obesity SURMOUNT-1 Trial In adults with obesity (without diabetes): Tirzepatide (15 mg) : 20.9% average body weight reduction over 72 weeks Semaglutide (2.4 mg) (based on STEP trials): ~14.9% average reduction STEP 5 Long-Term Results Semaglutide also demonstrated durable effects: At 104 weeks, patients maintained ~15% weight loss on semaglutide 2.4 mg (STEP 5) SELECT Trial Cardiovascular Benefit Semaglutide significantly reduced major adverse cardiovascular events by 20% in people with obesity and pre-existing heart diseaseindicating benefit beyond weight loss
Decaf Coffee Was Linked to Similar Benefits Researchers found similar associations for caffeinated and decaffeinated coffee
Lower circulating insulin levels allow your body's insulin receptors to become more responsive, breaking the cycle of resistance-driven weight gain
It adds to a growing body of evidence that glucagon-like peptide-1 (GLP-1) receptor agonists may have a place in tackling addiction to a variety of substances