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The SMILES trial (Supporting the Modification of Lifestyle In Lowered Emotional States) was the first randomized controlled trial to investigate the efficacy of a 12-week dietary intervention in the treatment of major depressive disorder.23 Researchers designed a modified Mediterranean diet based on the Australian Dietary Guidelines and the Dietary Guidelines for Adults in Greece

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10.1016/j.pharmthera.2021.107942 43 ThyagarajanA.SahuR

When it does so beneath the jawline, it sags visibly enough to look like a second chin