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Over the 8 residues spanning P4 to P4, it has 7 of 8 identical to the M pro site at the nsp12/nsp13 junction, with the only mismatch at the highly variable P3 position (Figure 1D), giving a near-perfect match to the M pro consensus

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While naturally occurring IGF-1 can enter the brain through specialised transport mechanisms in limited amounts, there is very little research specifically examining whether IGF-1 LR3 can do the same

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Zhang et al., 2009