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Metabolomics and lipidomics can identify substrate stress, mitochondrial bottlenecks, amino acid imbalance, redox dysregulation, and systemic drivers such as diabetes or chronic kidney disease ( This review synthesizes recent evidence on key metabolic derangementssubstrate inflexibility, mitochondrial dysfunction, BCAA accumulation, and ketone adaptationin myocardial hypertrophy, and critically examines their potential as clinically interpretable biomarker modules and therapeutic targets, while highlighting the persistent challenges in distinguishing adaptive from maladaptive remodeling and translating pathway signals into practice

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Pull the plunger back to the 1ml mark, drawing 1ml of air into the syringe

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Effect of metformin vs placebo on invasive disease-free survival in patients with breast cancer: the MA.32 randomized clinical trial