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More acidic or alkaline conditions may affect peptide stability or cause irritation

In fact, as of this writing, there is only one small retrospective study involving intra-articular knee injection into patients experiencing non specific knee pain

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Timing and food intake: Taking B12 supplements with or immediately after meals often reduces stomach upset significantly

But again, this is a generalization and could be different depending on the person and situation

Volume: Per-injection volume (~0.1 mL) is well below the 1.01.5 mL comfort threshold for subcutaneous administration [9]