Absorbed creatine undergoes limited phosphorylation (only 1% of ingested creatine) in the intestinal mucosa, and nearly 99% of orally ingested creatine enters the portal circulation (Jger et al
may reduce malondialdehyde, a marker of cell damage in the liver Improve blood sugar regulating hormone resistance: low glutathione levels are associated with less fat burning and higher rates of fat storing - supplementing may improve both Increase mobility in peripheral artery disease patients: when the peripheral arteries become clogged with plaque, glutathione may improve circulation, enabling patients to walk longer distances Reduce Parkinson's disease symptoms: intravenous glutathione may help reduce tremors and muscle rigidity Reduce oxidative damage in children with autism: these children have higher levels of oxidative damage and lower levels of glutathione in their brains
Tirzepatide already preserves lean mass better than most weight loss interventions due to its insulin-sensitising effects, so glutathiones added benefit in this context is uncertain
They can support energy metabolism and fat transport, especially in individuals with low B12 or metabolic sluggishness
But adding peptides increases complexity and potential for interactions
The presence of tannins and fragrance may be sensitizing
