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Some patients reported developing a flat affect

in Chemistry from the University of Bristol (United Kingdom)

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Some people lose more than 100 pounds in the first year, particularly those who started at higher weights and responded well to the medication

SURPASS-CVOT is a phase 3 study enrolled approximately 13,000 patients at least 40 years of age and have a diagnosis of type 2 diabetes, confirmed atherosclerotic cardiovascular disease, HbA1c 7.0% to 10.5% and a body mass index (BMI) 25 kilograms per meter squared (kg/m 2 )

Combination therapy was considered appropriate for adults with persistent kidney disease progression, high cardiovascular risk or suboptimal metabolic control