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There is a higher prevalence of type 2 diabetes mellitus (DT2) in patients with PsO than in the general population.25 In addition, insulin resistance induces dyslipidemia and contributes to the development of nonalcoholic hepatic steatosis (NAHS).26 Cardiovascular risk (CVR) is increased in patients with obesity and PsO who present psoriatic arthritis, and who often have other risk factors.27 The guidelines for the European Cardiology Society state that the body mass index (BMI) should not exceed 25kg/m2,28 and so early interventions to manage obesity or excess weight associated with PsO could contribute to preventing CVR

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Eli Lillys orforglipron Phase III trial (ATTAIN-MAINTAIN) enabled injectable-to-oral transitions, preserving most weight loss over 52 weeks

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