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Pathophysiology PD is caused by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta, resulting in striatal dopamine deficiency and the disruption of basal ganglia circuits

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IL-15 knockout mice with APAP overdose increase the infiltration of inflammatory cells and production of inflammatory cytokines, including IL-1, TNF-, IL-6, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), macrophage inflammatory protein (MIP) -1, MIP-2, leading to an overactive inflammatory response and enhances susceptibility to AILI [190]

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