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Immunocompromised state: Individuals with HIV, on immunosuppressive therapy for transplant or autoimmune disease, or with primary immunodeficiency should avoid Dihexa due to unknown immunological effects and cancer risk in this population

doi: 10.1042/bj1910421 44 ZimmermannMBAeberliI

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Exogenous melatonin has acute sleepiness-inducing and temperature-lowering effects during 'biological daytime', and when suitably timed (it is most effective around dusk and dawn), it will shift the phase of the human circadian clock (sleep, endogenous melatonin, core body temperature, cortisol) to earlier (advance phase shift) or later (delay phase shift) times

NSAIDs ameliorate cognitive and motor impairment in a model of parkinsonism induced by chlorpromazine

doi: 10.1002/cam4.3345 165 MukamaTSrourBJohnsonTKatzkeVKaaksR