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Paris 105 , 170182 (2011)
doi:10.1001/jamanetworkopen.2024.27258 38
Nature 654, 10551064 (2026)
These peptides are considered the most promising contenders in the upcoming anti-obesity market
The primary analytical challenges in semaglutide characterization arise from several structural features, including: Acylated lysine residue Fatty acid side chain Spacer/linker chemistry Multiple formulation-associated variants These modifications create substantial analytical heterogeneity that can complicate LC-MS workflows, chromatographic separation, ionization efficiency, and fragmentation analysis
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