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First, the evidence is limited to draw a definitive conclusion: only four small or moderate sized RCTs were included, and the risk of bias is generally moderate

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For CII assessment, 20 l succinate (100 mM), ADP (10 mM), rotenone (10 M) and plasma membrane permeabilizer (10 nM) were added to port A, 22 l oligomycin (10 g ml 1 ) was added to port B and 25 l antimycin A (A0149

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This leads to a visibly brighter and whiter complexion, addressing concerns like hyperpigmentation, dark spots, and uneven skin tone

158,161,164,165 However, activating multiple receptors may lead to more complex side effects, and in some experiments, dual and triple agonists have indeed shown more severe side effects