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While more research is necessary, repeated exposure to oscillatory hemodynamic stress and the associated patterns of shear stress on the endothelium may prime the vasculature to better handle both surges and sudden drops in systemic blood pressure, potentially leading to better maintenance and regulation of CBF during pressure challenges

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According to ClinicalTrials.gov, several bimolecular combinations alongside the dual GLP-1/GIP agonist tirzepatide are currently under investigation in phase 2 trials including eloralintide (NCT06603571), an amylin receptor agonist

Evidence type: Human RCT

Consequently, this format may be more marketable and thus likely to receive increased development interest and regulatory approval [13]

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