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A pegylated PLGA nanosystem loaded with the NSAID dexibuprofen partially crossed the BBB in a culture model, and significantly decreased the inflammation and -amyloid plaques in the hippocampal region of AD mice [78]

Amanakis G, Sun J, Fergusson MM et al (2021) Cysteine 202 of cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection

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doi: 10.1016/j.clineuro.2018.08.016