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As a result, GPX4 and GSH levels were markedly reduced, accompanied by elevated ROS levels and increased lipid peroxidation, collectively driving ferroptosis in cortical neurons and leading to neurodegeneration
Interaction effects between the nutritional state and carnitine levels were observed in the mRNA levels of ACC, FAS , and DGAT2 in liver and muscle, and ATGL and LPL in liver (Supplemental Table 3), showing nutritional state and L-carnitine both regulated the lipid synthesis and lipolysis
These are substantial elevations that persist far longer than any natural GHRH could maintain
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Ascorbic acid (vitamin C) is a reducing agent that binds to ARE, inhibits Nrf2 translocation to DNA, and decreases the levels of g-GCSl mRNA and GSH
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