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doi:10.1016/S0301-4622(02)00023-6

How GLP-1 Drugs Cause It: Slowing effect extends beyond the stomach Affects small intestine and colon Food or stool becomes stuck Can be life-threatening without treatment Symptoms: Severe abdominal pain and cramping Inability to pass gas or stool Severe bloating and distention Vomiting (may include fecal material) Loss of appetite Treatment: Often requires emergency hospitalization Nasogastric tube to decompress the stomach IV fluids and electrolytes Some cases require emergency surgery Risk of intestinal perforation or death if untreated Legal Claims: Patients who experienced bowel obstruction or ileus argue: This serious complication was not adequately disclosed Emergency room visits and surgeries could have been prevented Permanent bowel damage occurred Lost wages and medical bills are substantial Learn more about ileus warning signs and symptoms

Semaglutide is considered a long-term medication

Journal of clinical pharmacy and therapeutics 2021

Practices and Patients Beyond formal clinical trials, real-world results from clinical practice in the U.S

Some people experience mild changes in bowel habits, while others notice no digestive side effects at all