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While it is generally safe, melatonin is a potent hormone, originally extracted from a cows pineal gland, and it can have a number of adverse effects and drug interactions, ranging from nausea to increased blood pressure

doi: 10.1016/j.biopha.2018.09.049 94 XinWZhaoXLiuLXuYLiZChenLet al

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10.1056/NEJMoa2403347 N Engl J Med

J Exerc Nutr Biochem 23(4):14 Ye X et al (2021) The complete chloroplast genome of the medicinal plant Polygonum cuspidatum (Polygonaceae) and its phylogenetic implications within the subfamily Polygonoideae