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Hair loss is not listed as a known or direct adverse effect in the FDA prescribing information for Ozempic (semaglutide) or Wegovy (semaglutide for weight management)
Medications that receive more media attention about sexual side effects tend to generate more reports regardless of actual risk
increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin
In the PIONEER trial program, oral semaglutide 14 mg produced HbA1c reductions of approximately 1.0-1.4% and weight loss of 3-5 kg at 26-52 weeks, meaningful but below the efficacy achievable with injectable semaglutide 2.4 mg or tirzepatide
Patients who rely on semaglutide alone run the risk of regaining their lost weight after their treatment program
Glucagon-like peptide-1 (GLP-1)-based agents (including GLP-1 analogues and dipeptidyl peptidase 4 inhibitors) have been recently approved as new therapeutic options for patients with type 2 diabetes, based upon the evidence that GLP-1 can stimulate glucose-dependent insulin secretion from pancreatic cells
